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SWOG 1812: Interest and feasibility survey

S1812 Increasing Physical Activity in Colorectal Cancer Patients: A Factorial Trial

Recent observational studies suggest a strong protective effect of regular moderate-to-vigorous physical activity on survival following a colorectal cancer diagnosis. However, currently the large majority of CRC survivors do not meet recommended levels of physical activity. The purpose of S1812 is to identify the most efficacious combination of scalable physical activity intervention strategies to increase physical activity in CRC survivors.

Eligible participants (n=200) will have had a diagnosis of Stage I-III CRC, no evidence of metastatic disease and currently engage in <100 min/week of moderate to vigorous physical activity.

During the 12 month intervention, study participants will receive different combinations of physical activity supports with the goal of increasing their physical activity. Supports will include a Fitbit, a personal health coach, text messages, and a gym membership. Clinic staff will recruit and complete repeat clinical assessments of participants. The interventions will be delivered centrally by research staff at Fred Hutchinson Cancer Research Center and the University of Arizona Cancer Center.

Current plans are for clinic staff to be responsible for baseline height, weight, blood pressure, heart rate, blood draw and completion of questionnaires, as well as a physical function assessment. These measures will be repeated at 6 and 12 months. The estimated clinic staff time for each visit is 50 minutes, including completion of all questionnaires. All participant intervention materials will be mailed directly from the coordinating center at Fred Hutchinson Cancer Research Center.

Please complete the 5 minute survey below to help us assess interest and feasibility of S1812.

Would your clinical site be interested in participating in the trial?

Yes

Maybe

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If no, what are your reasons not to participate? Please check all that apply.

Don't have the eligible recruitment pool of patients

Don't have the staff time to allocate even with reimbursement

Our physicians would have low interest in this trial

Our patients would have low interest in this trial

Other

Other reason: please specify

Please estimate how many Stage I-III colorectal cancer patients your clinical site provides care for per year?

Other estimate: please specify

The eligibility criteria for S1812 are as follows:

  a. Age >18 years

  b. Previous diagnosis of Stage I-III colorectal cancer

  c. No evidence of recurrent/metastatic disease

  d. ≥60 days post-surgery and adjuvant chemotherapy (no minimal level of treatment is required, and there
   is no upper limit on time from treatment in order to keep the eligibility criteria broad and promote
   recruitment)

  e. Performance status Zubrod score of 0 or 1

  f. In the past 30 days, exercise to the point of sweating (MVPA) for < 100 min/week as assessed by brief
   screening questions

  g. Signed physician approval for regular MVPA

  h. Fluent in English or Spanish

What is the estimated number of patients your site could enroll in the trial per month?

Do you think your colorectal cancer patients would have interest in participating a physical activity trial?

Yes

Maybe

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If no, what are the reasons you think they would not be interested? Please check all that apply.

Low physical function

Too old

Too fatigued

Heavy symptom burden

No time

Other

Other reason: please specify

Do you think the majority (at least 75%) of your patients would agree to study related blood draws at baseline, 6 and 12 months?

Yes

Maybe

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We are considering adding a 6 minute walk test to demonstrate the impact of physical activity on physical function over time. The 6 minute walk test asks that the participant walk as far as they comfortably can in a 6 minute time period. To implement this test, clinics generally set a walking course within the clinic or surrounding area that the participant walks repeatedly until 6 minutes has lapsed, at which time the total distance walked is recorded. With training, could your study coordinators/research nurses conduct a 6 minute walk test with eligible colorectal cancer patients?

Yes

Maybe

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Could your study coordinators/research nurses assess oxygenation using pulse oximetry before and after the 6 minute walk test?

Yes

Maybe

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What is the name of your clinical site / institution?

What is the clinic site number (if you know it)?

What is your NCTN/NCORP clinic site type?

Community / NCORP

Minority-based NCORP

Academic

Other

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Other type: please specify

What is your name (optional)?

Would you be willing to be contacted for any follow-up questions?

Yes

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Phone number:

Email:

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